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The image above is from a research paper on daylight PDT and shows the skin penetration of different wavelengths of light produced by the sun.
On the left are ultraviolet rays, which may not penetrate so far but remain harmful, on the right is the infrared spectrum, which holds lower therapeutic properties. The section in the middle is visible light.
A range around 570 nm to 630 nm covers the best penetration and the most beneficial type of light, which works well with the photosensitising agent used in PDT. No surprise that Indoor Lux produces exactly that range.
There is a fair amount of research on open air, natural daylight PDT, which is used in a variety of countries. Trials over a decade have shown the approach to be reasonably effective, although limitations are noted.
Whilst you can protect against UV rays to a degree, they are still there. The season, weather and time of day bring restrictions. Installing a greenhouse has been tried and helps but better solutions have arrived.
Studies On Artificial Daylight PDT
The British Journal of Dermatology did carry a paper on the potential of indoor PDT as far back as 2014. A European study in 2018 took a similarly positive stance but for a new treatment, we should look at recent research.
In 2021, a study showed artificial daylight PDT to be nearly pain free and efficient. 85% of lesions were completely cleared up, the remaining lesions showed an average of over 40% reduction in size.
A 2022 randomised clinical trial of conventional versus indoor daylight PDT concluded that the indoor version was highly effective. An equal match for traditional PDT, without the normal levels of pain, or inflammation.
A systematic review in the same year concluded that daylight PDT is almost painless, gentle and as valuable as standard PDT. They confirmed that indoor photodynamic therapy was especially tolerable and as effective as other types.
Simulated daylight photodynamic therapy is a new treatment and more research will doubtless take place. That said, we can not find any which offers a negative view, or which disagrees with the core conclusions.
A Strong Scientific Base
Although seen as a new treatment, simulated daylight PDT is more a new delivery system, built on established knowledge. Photodynamic therapy and related sensitising agents have been developed over a long period.
This delivery system removes pain, or other unwanted downsides, or the unavailability of natural daylight PDT. The way Indoor Lux works is also less random and control matters to treatment in dermatology.
Research to date points to artificial daylight PDT being a notable success. Providing curative treatment for actinic keratosis, or other conditions, without patients being concerned about unwanted side effects.